• The SNP is within the Acetyl-coenzyme A carboxylase beta (ACACB) gene (R).

  • The gene is important in fatty acid synthesis and preventing fatty acid oxidation (R).

The A (minor) allele is associated with:

  • Increased risk of metabolic syndrome. This is especially true in individuals with a high fat intake (over 35%) (R).
  • Increased BMI and decreased insulin sensitivity (R).
  • Increased risk of obesity (R).


Parent Gene: ACACB

Importance: 3
Less common allele: A = 27%
More common allele: G = 73%
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