[PMID 19110417] hepatocellular carcinoma in Chinese populations

  • increased risk rs4646421 (OR 1.30, 95% CI 1.05-1.61)
  • increased risk rs2198843 (OR 1.33, 95% CI 1.05-1.69)
  • reduced risk rs4886605 (OR 0.70. 95% CI 0.52-0.94)


[PMID 17160896] Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.


[PMID 18268125] Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns.


[PMID 18632753] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.


[PMID 18691756] Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.


[PMID 18778477] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.


[PMID 18798002] Coffee consumption, genetic susceptibility and bladder cancer risk.


[PMID 19330903] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.


[PMID 19567509] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.


[PMID 24320736] Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study


[PMID 23816456] CYP1A1 genetic polymorphism and polycyclic aromatic hydrocarbons on pulmonary function in the elderly: haplotype-based approach for gene-environment interaction


[PMID 22521834] Genetic variations of CYP2B6 gene were associated with plasma BPDE-Alb adducts and DNA damage levels in coke oven workers.

rs4646421

Parent Gene: CYP1A1

Importance: 1
Less common allele: A = 32%
More common allele: G = 68%
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