Mechanism:

  • Higher levels of COMT . lower levels of dopamine. Lower levels of norepinephrine (CC)
  • Medium COMT activity (CT)
  • Lower COMT activity. Higher levels of dopamine. Higher levels of norepinephrine. (TT)

The Minor "T" allele is associated with:

  • Boys with TT had worse cognitive performance when acutely exposed to mercury. (R)
  • Higher risk of endometrial cancer [R].

The Major "C" allele is associated with:

  • Higher risk of atherosclerosis in women [R].

rs4633

Parent Gene: COMT

Importance: 2
Less common allele: T = 37%
More common allele: C = 63%
My Genotype: Log In