rs4570625 is a SNP in the TPH2 gene. It is significantly associated with Anxiety symptoms.

''G'' allele polymorphisms were found to be associated with a reduction in the NGA (Nogo-anteriorization) in both healthy controls and Attention-deficit/hyperactivity disorder (ADHD) patients [R].

Among healthy individuals, ''T'' allele carriers were associated with significantly smaller volumes in bilateral amygdala and hippocampus and higher reward dependence than those with ''G'' allele homozygotes [R].

The ''T'' allele was significantly less frequent in the Panic Disorder (PD) patients [R].

''G'' allele was preferentially transferred to children and adolescents with obsessive-compulsive disorder (OCD) [R].

Exaggerated amygdala activation in response to emotional facial stimuli has also been reported in carriers of ''T'' alleles, compared with the ''G'' allele homozygotes [R1, R2].

 

 

rs4570625

Parent Gene: TPH2

Importance: 2
Less common allele: T = 35%
More common allele: G = 65%
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