A very small study of 117 healthy European peri- and postmenarcheal girls (14.9 +/- 1.6 years) were followed for 4 years along with their calcium intake. Girls with rs4516035(C;T) and (C;C) genotypes had 13% lower spine mineral content if their milk intakes were below 260 mL/day, compared to either genotype-matched girls with higher milk intakes or to girls with the (T;T) genotype. If this is real, it suggests that rs4516035(C;T) and (C;C) female teens need more milk than rs4516035(T;T) girls to have optimal bone density.

[PMID 19105801] rs4516035 and the more aggressive tumour location in head-neck and trunk (OR=1.54, p=0.020)

[PMID 18587672] Vitamin D receptor variants and breast cancer risk in the Polish population

[PMID 20046590] The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma

[PMID 20394945] Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment

[PMID 21365644] Vitamin D receptor polymorphisms in patients with cutaneous melanoma

[PMID 22544453] Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma

[PMID 17130574] Protection from type 1 diabetes by vitamin D receptor haplotypes.

[PMID 18205531] Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users.

[PMID 19309297] Higher milk requirements for bone mineral accrual in adolescent girls bearing specific caucasian genotypes in the VDR promoter.

[PMID 19450131] Application of pharmacogenomics to vaccines.

[PMID 19615888] Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.

[PMID 19679055] Vitamin D receptor variants and the malignant melanoma risk: a population-based study.

[PMID 19682379] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.

[PMID 20015871] Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia.

[PMID 20398755] Growth, calcium status and vitamin D receptor (VDR) promoter genotype in European children with normal or low calcium intake.

[PMID 20716226] Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis.

[PMID 26303648] Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk


Parent Gene: VDR

Importance: 1
Less common allele: C = 18%
More common allele: T = 82%
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