Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 3x per copy of the major (A) allele at rs3782179 and rs4474514 (OR = 3.08, CI: 2.29–4.13; OR = 3.07, CI = 2.29–4.13, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the c-KIT ligand KITLG gene have a 4.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [PMID 19483682]

SNPs from the same gene were also implicated in testicular cancer risk in a study of 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls.[PMID 19483681]

[PMID 21551455] A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.

[PMID 22072546] Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.

[PMID 24083421] SNPs in KIT and KITLG genes may be associated with oligospermia in Chinese population

[PMID 23771924] Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition.


Parent Gene: KITLG

Importance: 2
Less common allele: G = 37%
More common allele: A = 63%
My Genotype: Log In
Risk Allele: A

Disease/Trait: Testicular Carcinoma

The A allele of rs4474514 is reported to be associated with Testicular Carcinoma (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Testicular cancer.