Mechanism:

  • Atypical Antipsychotics (AAPs) greatly decrease dopamine receptor sensitivity to below normal levels (CC) [R]
  • AAPs decrease dopamine receptor sensitivity to normal levels (C) [R]
  • AAPs decrease dopamine receptor sensitivity to normal levels (T) [R]

The Minor “C” allele is associated with:

  • Significantly increased the risk of Body Weight Gain (BWG) (CC). [R]

  • Decreased verbal fluency. [R]

    • Based on results of Divergent Thinking (DT) tests

The Major “T” allele is associated with:

  • Normal risk of Body Weight Gain (BWG) (CT and TT). [R]

  • Normal risk of verbal fluency. [R]

rs4436578

Parent Gene: DRD2

Importance: 2
Less common allele: C = 35%
More common allele: T = 65%
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