rs438034 is a SNP in the centromere protein F CENPF gene.

Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99). [PMID 19008095]


Parent Gene: CENPF

Importance: 5
Less common allele: A = 38%
More common allele: G = 62%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Response To Antineoplastic Agent

The T allele of rs438034 is reported to be associated with Response To Antineoplastic Agent (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Response to antineoplastic agents.