Only for Hispanics, individuals who have a genoset composed of rs1799913(C;C) and rs4290270(T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012).[PMID 18181017]


[PMID 19352219] Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder

[PMID 19763617] Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease


[PMID 21620479] Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population


[PMID 17167340] Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees.


[PMID 17453063] Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.


[PMID 18698231] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.


[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 20126463] Alternative splicing and extensive RNA editing of human TPH2 transcripts.


[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.


[PMID 21172166] Pharmacogenetics of antidepressant response.


[PMID 21937687] Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.


[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.


[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.


[PMID 26028568] Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population


[PMID 26057341] Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population


[PMID 26232682] Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms

rs4290270

Parent Gene: TPH2

Importance: 1
Less common allele: T = 49%
More common allele: A = 51%
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