[PMID 21248262] The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1

[PMID 21968104] The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study

[PMID 17443229] Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.

[PMID 18451331] Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation.

[PMID 18635889] Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.

[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

[PMID 19104506] Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer.

[PMID 19347053] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

[PMID 19729864] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.

[PMID 19934104] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

[PMID 20031576] Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.

[PMID 20031590] The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations.

[PMID 22205395] Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans.

[PMID 24233813] Stroke, IL-1ra, IL1RN, Infection and Outcome

[PMID 23602982] IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease


Parent Gene: IL1RN

Importance: 1
Less common allele: C = 24%
More common allele: T = 76%
My Genotype: Log In