May modulate other variations. Also known as the +2018T/C SNP.

In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the rs419598(C) allele are at 0.29x lower CP risk (p = 0.016).[rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").


[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes


[PMID 19290009] Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men

[PMID 20709104] Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans

[PMID 19934104] Radiographic severity of knee osteoarthritis is conditional on Interleukin 1 Receptor Antagonist gene variations


[PMID 22322675] IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study.


[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 16842617] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.


[PMID 17176440] The different expression patterns of interleukin-1 receptor antagonist in systemic lupus erythematosus.


[PMID 17665434] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.


[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18063673] Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.


[PMID 18615156] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.


[PMID 19043479] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.


[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.


[PMID 20975573] Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.


[PMID 21146623] Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.


[PMID 21279638] Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.


[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.


[PMID 23192617] IL-1RN +2018T>C polymorphism is correlated with colorectal cancer


[PMID 23212299] Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth


[PMID 23765978] Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis


[PMID 23602982] IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort


[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.


[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 24008079] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts


[PMID 25865535] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia


[PMID 25398456] IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation


[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

rs419598

Parent Gene: IL1RN

Importance: 1
Less common allele: C = 19%
More common allele: T = 81%
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