rs4149601 has been associated with hypertension. This SNP by itself was associated with diastolic blood pressure (DBP) (p=0.03) and DBP progression over time (p=0.04); in genotypic combination with intronic NEDD4L SNP rs2288774 it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time.[PMID 16788695]

[PMID 21052022] A functional variant of the NEDD4L gene is associated with beneficial treatment response with ?-blockers and diuretics in hypertensive patients

[PMID 17487281] Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.

[PMID 18268134] Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.

[PMID 18293164] Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.

[PMID 18591455] Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.

[PMID 19156173] Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population.

[PMID 19635985] A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.

[PMID 20003179] Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.

[PMID 20038744] Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.

[PMID 21154329] [Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].

[PMID 23353631] Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics

[PMID 23549273] A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.


Parent Gene: NEDD4L

Importance: 1
Less common allele: A = 28%
More common allele: G = 72%
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