Something seems wrong between dbSNP and the results from 23andMe and FTDNA. See Talk:Rs4148323 for more information.

rs4148323, a SNP also known as 211G>A or G71R, occurs in the UGT1A1 gene, and defines the UGT1A1*6 allele. This allele is associated with Gilbert's syndrome among Asians, Crigler-Najjar syndrome type II (CN-II), and transient familial neonatal hyperbilirubinemia.

[hyperbilirubinemia.

[PMID 19343046] rs4148323 and several other nearby SNPs help predict serum total bilirubin levels, based on a study of 750 Japanese.


[PMID 19238116] Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population

 


[PMID 20639394] Genome-wide association of serum bilirubin levels in Korean population

 

[PMID 22514612] Genetic Variations and Haplotype Diversity of the UGT1 Gene Cluster in the Chinese Population

 

 

 

[PMID 17424838] [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].


[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.


[PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].


[PMID 19482841] Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.


[PMID 19572200] Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes.


[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.


[PMID 23371916] A Genome-Wide Association Study for Serum Bilirubin Levels and Gene-Environment Interaction in a Chinese Population


[PMID 26413716] A GWAS Study on Liver Function Test Using eMERGE Network Participants

rs4148323


Importance: 5
Less common allele: A = 3%
More common allele: G = 97%
My Genotype: Log In
Risk Allele:

Disease/Trait: Bilirubin Measurement

rs4148323 is associated with Bilirubin Measurement (R) . It is reported to have a 0.14 bilirubin level increase on Bilirubin levels Conditional on rs11891311. No specific risk allele was identified in the study.

Disease/Trait: Bilirubin Measurement

rs4148323 is associated with Bilirubin Measurement (R) . It is reported to have a 0.121 unit increase on Bilirubin levels (Indirect bilirubin). No specific risk allele was identified in the study.

Disease/Trait: Bilirubin Measurement

rs4148323 is associated with Bilirubin Measurement (R) . It is reported to have a 0.09 unit increase on Bilirubin levels (Direct bilirubin). No specific risk allele was identified in the study.

Disease/Trait: Bilirubin Measurement

rs4148323 is associated with Bilirubin Measurement (R) . It is reported to have a 0.109 unit increase on Bilirubin levels (Total bilirubin). No specific risk allele was identified in the study.