rs41295061 increases susceptibility to Type I Diabetes 1.67 times for heterozygotes (AC) and 2.27 times for homozygotes (CC) [PMID 17676041]

[PMID 19265545] Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.

[PMID 19794070] A cis-Acting Regulatory Variant in the IL2RA Locus

[PMID 20033399] Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects

[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18776148] Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.

[PMID 19106270] Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.

[PMID 19116909] Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.

[PMID 19119414] IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

[PMID 19125193] IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

[PMID 19956099] The type I diabetes association of the IL2RA locus.

[PMID 19956106] Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

[PMID 20179739] Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.

[PMID 20236493] The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.

[PMID 20849903] Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.

[PMID 21815908] A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor.

[PMID 21875375] Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.


Parent Gene: RPL32P23

Importance: 1
Less common allele: A = 3%
More common allele: C = 97%
My Genotype: Log In