The T (minor) allele is associated with:

  • lower risk of heat disease
  • Lower Tumor Necrosis Factor-alpha (TNF) (possible decreased inflamation) (R).
  • Lower levels of MMP-9 protein (R).
  • Higher levels of Adiponectin (P=.026, causing more glucose metabolism and more fatty acid breakdown (R).
  • Reduced risk of developing Coronary Artery Disease compared with the CC homozygotes (odds ratio 0.547, P = .012) (R).
  • Lower fasting blood sugar levels (P = .032) and lower white blood cell count (P= .02)(R).
  • Decreased Bone Mineral Density. (R)
  • T is protective against psoriatic arthritis. (R)
  • The T allele was more frequent in overweight people (BMI >25) (P < 0.05) (R).


Parent Gene: PPARG

Importance: 4
Less common allele: T = 13%
More common allele: C = 87%
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