The T (minor) allele is associated with:
- lower risk of heat disease
- Lower Tumor Necrosis Factor-alpha (TNF) (possible decreased inflamation) (R).
- Lower levels of MMP-9 protein (R).
- Higher levels of Adiponectin (P=.026, causing more glucose metabolism and more fatty acid breakdown (R).
- Reduced risk of developing Coronary Artery Disease compared with the CC homozygotes (odds ratio 0.547, P = .012) (R).
- Lower fasting blood sugar levels (P = .032) and lower white blood cell count (P= .02)(R).
- Decreased Bone Mineral Density. (R)
- T is protective against psoriatic arthritis. (R)
- The T allele was more frequent in overweight people (BMI >25) (P < 0.05) (R).