rs3846662 is a SNP in the HMGCR gene. It is significantly associated with low-density lipoprotein (LDL) cholesterol measurement.
''G'' allele was associated with higher low-density lipoprotein (LDL-C) levels. This risk allele was more prevalent in subjects with myocardial infarction (MI) than in subjects without MI (nominal P=0.0038) [R].
GG genotype was a significant determinant for higher low-density lipoprotein (LDL-C) cholesterol-lowering response to atorvastatin [R].
''G'' allele carriers appear to be at greater risk for Alzheimer's disease (AD) [R].
Homozygosity for the minor allele ''A'' was associated with a 2.2 fold lower expression of alternatively spliced 3hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase (HMGCR) mRNA and low-density lipoprotein (LDL) levels [R].