rs3846662 is a SNP in the HMGCR gene. It is significantly associated with low-density lipoprotein (LDL) cholesterol measurement.

''G'' allele was associated with higher low-density lipoprotein (LDL-C) levels. This risk allele was more prevalent in subjects with myocardial infarction (MI) than in subjects without MI (nominal P=0.0038) [R].

GG genotype was a significant determinant for higher low-density lipoprotein (LDL-C) cholesterol-lowering response to atorvastatin [R].

''G'' allele carriers appear to be at greater risk for Alzheimer's disease (AD) [R].

Homozygosity for the minor allele ''A'' was associated with a 2.2 fold lower expression of alternatively spliced 3hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase (HMGCR) mRNA and low-density lipoprotein (LDL) levels [R].

rs3846662

Parent Gene: HMGCR

Importance: 5
Less common allele: A = 38%
More common allele: G = 62%
My Genotype: Log In
Risk Allele: G, G

Disease/Trait: Low Density Lipoprotein Cholesterol Measurement

The G allele of rs3846662 is reported to be associated with Low Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with LDL cholesterol.

Disease/Trait: Total Cholesterol Measurement

The G allele of rs3846662 is reported to be associated with Total Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholesterol, total.