rs3828599 is a SNP of the of GPx-3 gene. It is significantly associated with hypertension.
An individual with at least 1 ''A'' allele had a decreased risk of differentiated thyroid cancer (DTC) compared with an individual of the GG homozygote (sex- and age-adjusted OR = 0.53, P = .018). Hence the ''A'' allele may exert a protective effect for DTC [R].
''A'' allele frequency was significantly lower in hypertensives than those in controls (35.6% vs. 40.8%, P = 0.009) [R].