rs3825932 in the CTSH gene confers a risk for type 1 diabetes (T1D), but is associated with a reduced risk of diabetic eye disease.

The ''T'' allele  was associated with lower candidate gene cathepsin H (CTSH) expression in human lymphoblastoid cell lines and pancreatic tissue in patients with type 1 diabetes (T1D) [R].  

Variant C > T genotype was associated with reduced risk of progression to proliferative diabetic retinopathy (PDR) (OR [95 % CI] = 0.20 [0.07-0.56], p = 2.4 × 10(-3), padjust = 0.048) [R].

 

rs3825932

Parent Gene: CTSH

Importance: 4
Less common allele: C = 37%
More common allele: T = 63%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Type I Diabetes Mellitus

The T allele of rs3825932 is reported to be associated with Type I Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 1 diabetes.

Disease/Trait: Type I Diabetes Mellitus

rs3825932 is associated with Type I Diabetes Mellitus (R) . It is reported to association with Type 1 diabetes. No specific risk allele was identified in the study.