Patients with extensive ulcerative colitis (UC) carrying the ''T'' allele showed increased susceptibility to inflammatory bowel disease (IBD) compared with left-sided colitis patients and with healthy subjects [R]. 

The CC genotype was associated with an increased risk of flucloxacillin-induced DILI (Drug-induced liver injury) (odds ratio = 3.37, P = 0.0023) [R].  

Patients with the TT genotype significantly had a greater risk of antituberculosis drug-induced liver injury (AT-DILI) (OR 8·89; P < 0·05), compared with those with CC genotype [R].



Parent Gene: NR1I2

Importance: 2
Less common allele: T = 32%
More common allele: C = 68%
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