Mechanism:

The Minor “A” allele is associated with:

  • Higher food intake from the age of three to four years old (R).

  • Reduced gene expression (Less transcriptional activity) (R).

  • Vulnerability to weight gain after antipsychotic treatment (R).

The Major “G” allele is associated with:

  • Associated with the same mutation in the rs3813929 nucleotide (R).

  • Increased risk of obesity in non-psychiatric patients using antipsychotic drugs (R).

  • Antipsychotic drug-induced weight gain (R).

  • Better regulation of appetite and body weight due to increased Serotonin receptor (R). 

  • Association with side effects of antipsychotic drugs in male chronic schizophrenic patients (R)

This SNP is associated with (Unknown which alleles):

  • High in tissue damage (Lactate Dehydrogenase) ( R )

  • Higher risk of suicide ( R )

  • Increased risk of heart problems (cardiovascular morbidity) ( R )

  • Severe depression among coronary heart disease patients ( R )

  • (89%) of patients developed schizophrenia or schizoaffective disorder (R)

rs3813928

Parent Gene: HTR2C

Importance: 5
Less common allele: A = 14%
More common allele: G = 86%
My Genotype: Log In