rs3807306 is a SNP located in the IRF5 gene. It is significantly associated with autoimmune disorders.

The GG genotype (p = 0.03) was associated with protection from ulcerative colitis (UC) [R].

The ''G'' allele was a risk factor for Crohn's disease (CD) (OR 2.3630, P = 0.00004), whereas the homozygous ''T'' genotype was protective against the disease (OR 0.2038, P = 0.00004) [R].

The ''T'' allele was significantly associated with Systemic lupus erythematosus (SLE) (P=0.02) [R].

The ''T'' allele was associated with human herpes virus-6 (HHV-6) infection (p=0.05, OR =1.56) and response to IFN-β therapy (P=0.09, OR =1.39) [R].

 

rs3807306

Parent Gene: IRF5

Importance: 2
Less common allele: T = 35%
More common allele: G = 65%
My Genotype: Log In
Risk Allele:

Disease/Trait: Rheumatoid Arthritis

rs3807306 is associated with Rheumatoid Arthritis (R) . It is reported to increased association with Rheumatoid arthritis (ACPA-negative RA vs controls). No specific risk allele was identified in the study.