TT genotype carriers and H.pylori infectors had higher susceptibility to gastric cancer (OR = 3.42), compared with TC + CC genotype carriers and non-H.pylori infection group [R].

Compared with those carrying wild-type homozygous genotypes (T/T), risk of hepatocellular carcinoma (HCC) decreased significantly in individuals carrying the heterozygous genotypes (C/T)  (adjusted odds ratio (OR), 0.493, P < 0.01) [R]. 

The ''C'' allele was associated with higher National Institute of Health Stroke Scale (NIHSS) scores (p = 0.0003) in ischemic stroke patients [R]. 

Healthy subjects who were positive for the CT/TT alleles had a superior innate immune response to L. pneumophila than other genotypes [R]. 

TT genotype and reported sexual abuse was responsible for determining an earlier age at onset of bipolar disorder (BD) (p = 0.002; corrected p = 0.02) [R]. 


Parent Gene: TLR2

Importance: 2
Less common allele: C = 42%
More common allele: T = 58%
My Genotype: Log In