The C (major) allele is associated with:

  • CC had more DNA damage than those with one or two T's (measured by urinary 8-OHdG...168 for CC vs 151 for a T allele. P = 0.030) (R).
  • This may lead to an increased risk of cancer or cellular malfunction.

rs3774923

Parent Gene: PPARGC1A

Importance: 3
Less common allele: T = 10%
More common allele: C = 90%
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