rs3757385 is a SNP of the IRF5 gene. It is significantly associated with systemic sclerosis (SSc), and is also linked with rheumatoid arthritis (RA) [R1R2].

G/G homozygous individuals were at higher risk of acute rejection of liver transplantation, with a P value of 0.042 (OR = 2.34) [R].




Parent Gene: IRF5

Importance: 2
Less common allele: T = 50%
More common allele: G = 50%
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