rs3750344 is a SNP of the GABBR2 gene. It may be associated with nicotine dependence (ND), with the minor allele  ''C'' showing a positive association [R].

The ''T'' allele was negatively associated with HSI (Z = −2.88, P = 0.004) and FTND (Z = −3.20, P = 0.001) in African- Americans (AAs), whereas the ''C'' allele (frequency 7.4%) was positively associated with SQ (Z = 2.68, P = 0.007) in European americans (EAs) [R].

FTND: Fagerström Test for Nicotine Dependence score

HSI: Heaviness of Smoking Index

SQ: Smoking Quantity (SQ; number of cigarettes smoked per day)


Parent Gene: GABBR2

Importance: 2
Less common allele: C = 16%
More common allele: T = 84%
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