Mechanism:

  • This SNP might alter microRNA binding and thus have an effect on SNAP-25 production.This SNP is assumed to influence the binding of microRNAs (miR SNPs), which can affect the function and production of the SNAP25 protein. This snp influences the function of two miRNAs (miR-510 and miR-641) in a special way (they affect the binding site of miR-641) (R).
  • SNP variants that produce less SNAP25 are associated with less activation in areas of the brain that are critical for the regulation of attention and inhibition (prefrontal cortex) (R).
  • Therefore, T=presumably lower SNAP25. SNAP25 influence expression within the IFG, with decreased SNAP-25 expression (as expected from the Coloboma mouse) associated with the ADHD risk variant (R).

The G (minor) allele is associated with:

  • GG=1.25X increased risk for schizophrenia (R).

The T (major) allele is associated with:

  • 1.15X risk for ADHD (p=.028) (R, R2).

rs3746544

Parent Gene: SNAP25

Importance: 3
Less common allele: G = 28%
More common allele: T = 72%
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