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rs3745274

Chromosome : 19 , Position: 41006936

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: T, A

Associated Genes

CYP2B6

MIA

CYP2A13

CYP2A7

CYP2F1

CYP2A6

AXL

CYP2S1

EGLN2

C19ORF54

HNRNPUL1

MIA-RAB4B

RAB4B

RAB4B-EGLN2

SNRPA

CCDC97

COQ8B

ITPKC

NUMBL

B9D2

TGFB1

TMEM91

B3GNT8

BCKDHA

EXOSC5

LTBP4

DMAC2

ERICH4

SHKBP1

SERTAD3

Summary

[PMID 21715435] Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens

[PMID 21790905] CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction

[PMID 21886015] Cytochrome P450 CYP2B6 genotypes and haplotypes in a Colombian population: identification of novel variant CYP2B6 alleles

[PMID 18728241] Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation.

[PMID 18784455] The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.

[PMID 19076156] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

[PMID 19154420] The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.

[PMID 19239339] Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.

[PMID 19371316] CYP2B6 (c.516G–>T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

[PMID 19659438] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.

[PMID 20459744] Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.

[PMID 20723261] Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients.

[PMID 21172166] Pharmacogenetics of antidepressant response.

[PMID 21694616] CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer.

[PMID 21854194] Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina.

[PMID 21860339] Integration of absorption, distribution, metabolism, and elimination genotyping data into a population pharmacokinetic analysis of nevirapine.

[PMID 23080225] Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants

[PMID 23249875] Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study

[PMID 22951632] Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine

[PMID 24080498] Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients

[PMID 24260284] CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes

[PMID 23133420] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

[PMID 23524664] Influence of the CYP2B6 polymorphism on the pharmacokinetics of mitotane.

[PMID 23996099] ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients

[PMID 25428516] Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer

[PMID 26141406] Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability

More Information

rs3745274 is linked to the CYP2B6 gene and is associated with drug response.

The ''G'' allele was found to be significantly associated with a higher clearance, a lower plasma concentration, and a lower concentration-to-dosage (C/D) ratio of (S)-methadone (P < 0.0017) [R].

Heterozygous patients (GT) showed a 15.3% reduced clearance of the drug nevirapine [R].

Presence of the ''T'' allele decreased the total required propofol dose. The total propofol doses based on the GG or GT/TT genotypes were 151.5 ± 64.2 mg and 129.3 ± 44.6 mg, respectively (p = 0.043) [R].

Population Alleles Frequency

ethhicity frequency	T	A
African/African-American	0.3698	–
Latino/Admixed American	0.2972	–
Ashkenazi Jewish	0.2448	–
East Asian	0.1846	–
European	0.2272	–
Other (population not assigned)	0.2376	–

Frequently Asked Questions

Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation Why Are Alleles for This SNP Different Elsewhere?

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rs3745274

Associated Genes

Summary

More Information

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Ultimate Bundle

Limited Time Offer 25% Off

Individual DNA Reports

Methylation Pathway - MTHFR Test

Histamine Intolerance DNA Pathway Report

Gut Health, Digestion & IBS DNA Report

Autoimmune Disease Risk & Prevention DNA Report

See all reports

Policies

About

Navigation

Health reports