Mechanism:

The C (major) Allele is associated with:

  • Increased vulnerability in nicotine dependence

  • Not correlated with a similar SNP (rs16969968) which also has a part in nicotine dependence vulnerability [R]

The G (minor) Allele is associated with:

  • Increased craving of nicotine

  • Indirect through craving

  • People with at least one G allele had higher scores on the craving scale, more cigarettes smoked, and higher scores on the Fagerstrom Test for Nicotine Dependence [R]

The SNP is associated with:

  • No correlation between nicotine dependency and level of parent monitoring [R]

  • Risk for nicotine dependence can be made less severe by environmental factors (like parent monitoring) [R]

rs3743078

Parent Gene: CHRNA3

Importance: 2
Less common allele: G = 44%
More common allele: C = 56%
My Genotype: Log In
Risk Allele: C

Disease/Trait: Forced Expiratory Volume

The C allele of rs3743078 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The C allele of rs3743078 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.