Mechanism:

  • Rs3741208 (A to G) is a variation in an intron in the IGF-2 gene (not part of the final product).
  • The mutation leads to lower amounts of IGF-2 being made. IGF-2 is involved in growth and repair of cells (R).

The Minor "A" allele is associated with:

  • Increased risk of developing type 1 Diabetes (R).

The Major "G" allele is associated with (lower IGF-1):

rs3741208

Parent Gene: IGF2, IGF2-AS, INS-IGF2

Importance: 2
Less common allele: A = 33%
More common allele: G = 67%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Type I Diabetes Mellitus

The T allele of rs3741208 is reported to be associated with Type I Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 1 diabetes.