AC/CC and CA/AA were associated with a moderately increased risk of developing a second primary malignancy (SPM) (adjusted hazard ratio [aHR], 1.48) in patients with index squamous cell carcinoma of the head and neck (SCCHN) [R].

After definitive chemoradiotherapy, HPV-positive oropharyngeal cancer patients having AC/CC variant genotypes had significantly better overall, disease-specific and disease-free survival than those having AA genotype, respectively [R].

AC/CC versus AA genotypes were significantly associated with an increased risk of differentiated thyroid carcinoma (DTC) (OR=1.7) [R]. 



Parent Gene: CDKN2A

Importance: 2
Less common allele: C = 12%
More common allele: A = 88%
My Genotype: Log In
Risk Allele:

Disease/Trait: B-Cell Acute Lymphoblastic Leukemia

rs3731217 is associated with B-cell Acute Lymphoblastic Leukemia (R) . It is reported to association with Acute lymphoblastic leukemia (B-cell precursor). No specific risk allele was identified in the study.