Mechanism:

  • Increased production of nitric oxide (C) [R]

  • Decreased production of nitric oxide (T) [R]

The Minor "T" allele is associated with:

  • Decreased risk for Large B-Cell lymphoma [R]

The Major "C" allele is associated with:

  • Increased risk for Large B-Cell lymphoma [R]

This SNP is associated with (unknown  which alleles):

  • Increased susceptibility to rheumatoid arthritis [R]

  • Increased risk for malaria [R]

rs3729508

Parent Gene: NOS2

Importance: 2
Less common allele: T = 32%
More common allele: C = 68%
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