Individuals carrying the ''G'' allele had an increased expression of IL18 and hence was associated with systemic lupus erythematosus (SLE) [R].

''G'' allele was significantly increased in giant-cell arteritis (GCA) patients (30.7%) compared with controls (23.0%) (P = 0.003; OR, 1.48). An increased susceptibility to GCA was observed in individuals carrying the G/G or the G/A genotypes compared with those carrying the A/A genotype (P = 0.005; OR, 1.61) [R].

The GG genotype exhibited a 2.536-fold increased risk of systemic lupus erythematosus (SLE) incidence (p=0.0035). We also found a significantly higher frequency of the ''G'' allele in patients than in controls, with odds ratio (OR) for the ''G'' allele in patients with SLE being 1.558 (p=0.0013). Moreover, there was an association between the GG genotype and renal manifestations of SLE, OR=3.792 (p=0.0051) [R].

''G'' allele was significantly associated with systemic lupus erythematosus (SLE) in all study subjects and in Europeans (OR = 1.240, p = 0.010 and OR = 1.303, p = 0.016) [R].



Parent Gene: IL18

Importance: 2
Less common allele: G = 21%
More common allele: A = 79%
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