The Minor "C" allele is associated with:
- Decreased levels of Neuregulin 1 (NRG1).
- Higher risk of neuroticism
- Decreased conscientiousness
- Less extraversion (in men), less openness (in men).
- The C allele is more common in Schizophrenics.
The Major "T" allele is associated with:
- T allele is more common in bipolar subjects.