rs324420 is linked to the FAAH gene. It is shown to be associated with drug abuse, and an increased risk for substance use disorders.

A/A genotype was associated with early onset and adult obesity [R].

AC genotype and the ''A'' allele are associated with anorexia nervosa and bulimia nervosa [R].

The homozygous minor allele (AA) was associated with lower HDL (high-density lipoprotein) levels [R]. 

Carriers of the AA genotype experienced greater reductions in circulating triglycerides and total cholesterol levels [R].

A psychoactive ingredient in cannabis helped people more with Irritable bowel syndrome with constipation (IBS-C) when they had ''CC'' genotype [R].

The ''A'' allele is associated with antipsychotic-induced weight gain [R].

A better response of weight, fat mass and waist circumference was observed in ''CC'' genotype subjects than A allele carriers under a high monounsaturated fat hypocaloric diet [R].

The ''C'' allele, would be associated with an increased blood oxygenated level dependent (BOLD) response to marijuana-related cues in reward-associated brain areas [R].

C/A genotype may predispose subjects to get a clinically meaningful weight gain after antipsychotic exposure [R].


Parent Gene: FAAH

Importance: 2
Less common allele: A = 26%
More common allele: C = 74%
My Genotype: Log In
Risk Allele: A
Significance: risk factor