rs324420 is linked to the FAAH gene. It is shown to be associated with drug abuse, and an increased risk for substance use disorders.
A/A genotype was associated with early onset and adult obesity [R].
AC genotype and the ''A'' allele are associated with anorexia nervosa and bulimia nervosa [R].
The homozygous minor allele (AA) was associated with lower HDL (high-density lipoprotein) levels [R].
Carriers of the AA genotype experienced greater reductions in circulating triglycerides and total cholesterol levels [R].
A better response of weight, fat mass and waist circumference was observed in ''CC'' genotype subjects than A allele carriers under a high monounsaturated fat hypocaloric diet [R].
The ''C'' allele, would be associated with an increased blood oxygenated level dependent (BOLD) response to marijuana-related cues in reward-associated brain areas [R].