rs3212227 is a SNP of the IL12B gene. It is significantly associated with an increased risk of cervical cancer and psoriasis.

TG/GG variant genotypes were associated with a significantly increased risk of cervical cancer. Also, genotypes having >2 parities showed a 6.00-fold elevated cervical cancer risk [R].

The ''T'' allele was significantly associated with psoriasis  (OR = 1.62, p = 1.7 × 10−15) [R].

The subjects carrying combined genotypes TG/GG at both loci had a 2.05-fold increased asthma risk compared with those carrying all other genotypes (p = 0.001) [R].

The genotypes TG/GG had a 2.62-fold increased risk of glioma (OR=2.62) [R].

Subjects carrying GG genotype had a significantly greater risk of developing ankylosing spondylitis (AS) than subjects with the TT genotype [R].

TG heterozygotes were more common among Chlamydia trachomatis-induced tubal factor infertility (TFI) cases than among controls (P = 0.009) and were associated with increased risk of TFI (OR = 2.44). Carrying the minor allele ''G'' was also associated with disease severity (P for trend = 0.008) and moderate (OR = 2.51) and severe tubal damage (OR = 2.73) [R].

GG genotype was associated with type 2 diabetes (T2D) [R].

 

 

rs3212227

Parent Gene: IL12B

Importance: 2
Less common allele: G = 36%
More common allele: T = 64%
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