This is a triallelic SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.


[C-reactive protein was associated with prevalent coronary heart disease in the non-Hispanic white population


[SLE and functional haplotypes containing rs3091244/rs3093062

According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.

[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity

[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21575917] C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants

[PMID 21831326] CRP gene variation affects early development of Alzheimer's disease-related plaques

[PMID 15897982] Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

[PMID 16534007] Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.

[PMID 16550411] Allelic spectrum of the natural variation in CRP.

[PMID 16723442] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17161935] Genotyping of triallelic SNPs using TaqMan PCR.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17903293] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 18162041] Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

[PMID 18167554] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18285551] Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

[PMID 18394581] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18704199] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18714384] The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

[PMID 18793001] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

[PMID 19076828] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

[PMID 19262552] C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19336475] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19426506] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

[PMID 19436291] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

[PMID 19545442] Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.

[PMID 19567438] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

[PMID 19946607] Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

[PMID 20031577] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

[PMID 20494378] Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.

[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 20714329] C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21496483] Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

[PMID 21647738] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

[PMID 21979869] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 22875596] Association study of CRP gene and ischemic stroke in a Chinese Han population

[PMID 23940726] Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population

[PMID 24135623] C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm

[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length

[PMID 25025473] Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk


Parent Gene: CRP, RPL27P2

Importance: 3
Less common allele: A = 24%
More common allele: None = None
My Genotype: Log In
Risk Allele:

Disease/Trait: C-Reactive Protein Measurement

rs3091244 is associated with C-reactive Protein Measurement . It is reported to have a 0.2 mg/dl increase on C-reactive protein. No specific risk allele was identified in the study.