Mechanism:

  • TT:higher VEGF plasma production [R]
  • TC:average VEGF secretion [R]
  • CC:lower VEGF production (loss of a potential binding site for AP-4 [R])

The T (minor) allele is associated with:

  • Increased vascular permeability [R]
  • Lowered risk for macular degeneration (AMD)[R]
  • Increased risk for non-alcoholic fat liver disease (NAFLD) [R]
  • Bisphosphonate-related osteonecrosis of the jaw (Korean population) [R]

The C (major) allele is associated with:

  • Increased susceptibility to gastric cancer [R]
  • Increased susceptibility to Diabetic Retinopathy(in Asian populations) [R]
  • Increased risk of early onset rheumatoid arthritis (<40 years old) [R]
  • Increased nervous system tumor susceptibility (study done only in Chinese populations) [R]
  • Increased risk of bone cancer [R]
  • Increased risk of high blood pressue [R]
  • Small-artery blockage (can lead to stroke) [R]
  • Susceptibility to breast cancer in Caucasians [R]
  • Susceptibility to recurrent spontaneous abortion [R]

 

rs3025039

Parent Gene: VEGFA

Importance: 3
Less common allele: T = 13%
More common allele: C = 87%
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