Mechanism:

This SNP is located in the intron region of the VEGF-A, meaning it can lead to the protein being bigger or smaller than it originally was. This can affect protein function (R).

The T (minor) allele is associated with:

  • Increased BMI (R).
  • Increased Risk of Diabetes and higher proinsulin (R).
  • Increased risk of Crohns Disease (R).
  • Increased risk of Ulcerative Colitis (R).
  • Increased risk of spontaneous Miscarriage (R).
  • Increased risk of Sarcoidosis (R).
  • Decreased Lower lung function (R).
  • Increased chance of seizures coming back (R).
  • Increased Flucloxacillin-induced liver injury (R).
  • Increased Protection against Ampulla of Vater Cancers (R).

The C (major) allele is associated with:

  • Increased height (R).
  • Poorer prognosis after anti-VEGF treatment with age related macular degeneration (R).
  • Higher risk of AMD (an eye condition) (R).
  • Poorer prognosis after anti-VEGF treatment for diabetic retinopathy (R).
  • Increased susceptibility to acute mountain sickness (R).

rs3025000

Parent Gene: VEGFA

Importance: 3
Less common allele: T = 24%
More common allele: C = 76%
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