The C-allele of PKLR rs3020781 was previously reported to be strongly associated with type-2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54].

However, in a combined study sample comprising a total of 16,801 and 16,913 individuals from Denmark, no significant association was found to diabetes or obesity .[PMID 19111066]


Parent Gene: PKLR

Importance: 1
Less common allele: G = 48%
More common allele: A = 52%
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