rs2910164 is a SNP of the MIR146A gene. It may be associated with higher cancer risk.
The ''GC'' heterozygous state was associated with an increased risk of acquiring Papillary thyroid carcinoma (PTC) (OR = 1.62, P = 0.000007), and both homozygous states were protective (OR = 0.42 for the CC genotype (P = 0.003) and OR = 0.69 for the GG genotype (P = 0.0006)) [R].
Breast/ovarian cancer patients with variant ''C'' allele may have high levels of mature miR-146 (micro RNA) [R].
Male individuals with the ''GG'' genotype were 2-fold more susceptible to hepatocellular carcinoma (HCC) (OR = 2.016, P = 0.034) compared with those with the ''CC'' genotype [R].
A significantly increased risk of cancer was found in males with the ''GG/GC'' genotypes (OR = 1.23), and the significance was more pronounced in smokers (OR = 1.82) than in non-smokers (OR = 1.24) [R].