Mechanism

Decreased ability to repair or destory damaged DNA. (T) [R]

Normal ability to repair or destory damaged DNA. (G) [R]

The Minor allele “T” is associated with:

  • Significantly increases risk of developing breast and ovarian cancer (TT and TG). [R]

    • TG risk is less significant than the TT variant.

The Major allele “G” is associated with:

  • Normal risk of developing breast and ovarian cancer (GG). [R]

rs28897696

Parent Gene: BRCA1

Importance: 5
Less common allele: None = None
More common allele: None = None
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