rs28371686, also known as 1080C>G, 42619C>G or D360E, is a SNP in the CYP2C9 gene.

The rs28371686(G) allele defines the CYP2C9*5 variant, which appears to have decreased activity.

[PMID 20214591] Pharmacogenomics in aspirin intolerance

[PMID 18466099] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

[PMID 18752379] Warfarin pharmacogenetics.

[PMID 23133420] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


Parent Gene: CYP2C9

Importance: 1
Less common allele: G = 0%
More common allele: C = 100%
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