rs28365083, also known as 27289C>A, is a SNP in the CYP3A5 gene.

The rs28365083(A) allele defines the CYP3A5*2 variant, which is nonfunctional.

[PMID 17615053] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 19076156] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.


Parent Gene: CYP3A5

Importance: 1
Less common allele: T = 0%
More common allele: G = 100%
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