This SNP in the GABRA2 gene has been linked to Alcoholism. The effect of this SNP, a synonymous change at amino acid residue 132, is unknown, but it does not change the GABRA2 protein sequence.

Carriers of at least one (G) allele respond slower to the effects of alcohol and are thereby apparently more prone to alcoholism than carriers of two (A) alleles.

Finasteride, an FDA approved drug for the treatment of benign prostatic hypertrophy and a modulator of GABRA2, was shown to have more of a blocking effect on (A) homozygotes.

[PMID 15702134] Note that nearby SNPs have been grouped into a haplotype that shows statistically stronger association with alcohol dependence, namely the haplotype consisting of the (A) + (T) + (A) alleles [PMID 15024690].


Parent Gene: GABRA2

Importance: 1
Less common allele: C = 36%
More common allele: T = 64%
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