A study of 151 Korean families reported that the rs2745557(A) allele of the PTGS2 gene, also known as cyclooxygenase-2 (Cox-2), was overtransmitted (p<0.01) in autism spectrum disorders.[PMID 18579107]

[PMID 19820421] The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey

[PMID 21705955] Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility

[PMID 17609663] COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.

[PMID 18038187] Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma.

[PMID 18085997] Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

[PMID 18682823] Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.

[PMID 18768181] Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

[PMID 19318492] Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

[PMID 19437564] No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19560328] No association between the PPARG gene and schizophrenia in a British population.


Parent Gene: PTGS2

Importance: 1
Less common allele: A = 15%
More common allele: G = 85%
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