The Minor "A" allele is associated with:
- Higher levels of enzyme and had lower Estradiol (AA)
- Higher inactive metabolites (AA)
- Each A lowers risk for lung cancer in subjects who never smoked (50%), but increases risk in people who have smoked. This might be because AA will break down carcinogens fast, but if you have a higher toxin load, it will cause too high of a toxin buildup.