rs25532 is linked to the 5-HTTLPR gene. It may be associated with obsessive compulsive disorder (OCD).
rs25532 is a SNP in a regulatory region upstream of the serotonin transporter SLC6A4 gene. The more common 'G' allele is the higher-expressing allele.
A study of patients with obsessive compulsive disorder (OCD) concluded that the major 'G' allele was a major contributor to the association of a corresponding haplotype with this disorder [R]
The minor allele 'A' is almost always in phase with the long (L) allele of 5-HTTLPR.[R]
The ''G'' allele was significantly associated with Tourette disorder (TD) (a neurological disorder) [R].
The minor allele significantly decreased luciferase reporter gene expression levels by 15-80%, depending on 5-HTTLPR allele background and cell type, and hence may be associated with obsessive compulsive disorder (OCD) [R].