• ABCA1 gene is important in maintaining cholesterol balance in the cell (R).

The A (minor) allele is associated with:

  • Significantly increased risk of developing Alzheimer’s disease (R).
  • Increased risk of developing primary open-angle glaucoma (R), but not primary angle closure glaucoma (R).
  • 7.5% decreased risk of death due to cardiovascular disease (AA) (R).

Heterozygous associations: 

  • 3.6% decreased risk of death due to cardiovascular disease (AG) (R).

rs2422493

Parent Gene: ABCA1

Importance: 2
Less common allele: A = 49%
More common allele: G = 51%
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