The A (Minor) allele is associated with:

  • AA=Increased responsiveness to homocysteine-lowering effects of folic acid.
  • Limited homocysteine in the body (mixed evidence)
  • Possible increased risk of sulfur toxicity if too much sulfur is ingested due to lower homocysteine levels.
  • Increased risk for ammonia detoxification issues

*Some believe this allele increases the activity of the CBS enzyme, but presently the activity of this enzyme has never been measured.


Parent Gene: CBS

Importance: 1
Less common allele: A = 20%
More common allele: G = 80%
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