The A (Minor) allele is associated with:
- AA=Increased responsiveness to homocysteine-lowering effects of folic acid.
- Limited homocysteine in the body (mixed evidence)
- Possible increased risk of sulfur toxicity if too much sulfur is ingested due to lower homocysteine levels.
- Increased risk for ammonia detoxification issues
*Some believe this allele increases the activity of the CBS enzyme, but presently the activity of this enzyme has never been measured.