Mechanism:

  • Normal levels of Glycogen Synthase Kinase 3 Beta (GSK3B) in the body (AA).
  • Normal levels of GSK3B in the body (A).
  • Possible increased levels of GSK3B in the body (G) [R].
  • GSK3B is important in energy metabolism and neural cell development in the body [R].

The Minor "C" allele is associated with:

  • Poorer response to antidepressants given to patients with Major Depressive disorder (MDD) [R].
  • Possible increased risk of Major Depressive Disorder (MDD) [R].
  • Higher levels of GSK3B cause increased the risk of developing bipolar disorder [R].
  • Possible increased risk of Polycystic Ovary syndrome (PCOS) [R]. This may cause irregular menstrual cycle or no menstrual cycle at all. [R] Other symptoms may include male features (due to the production of male hormones) and difficulty getting pregnant [R].
  • High levels of GSK3B could lead to Alzheimer's disease [R].

The Major "A" allele is associated with:

  • Increased response to antidepressants given to patients with MDD [R].
  • Possible decreased the risk of MDD [R].
  • Lower levels of GSK3B could lead to less risk of Alzheimer's disease, bipolar disorder, and PCOS [R][R][R].

rs2319398

Parent Gene: GSK3B

Importance: 2
Less common allele: C = 41%
More common allele: A = 59%
My Genotype: Log In